{"id":1087,"date":"2018-12-18T15:08:07","date_gmt":"2018-12-18T20:08:07","guid":{"rendered":"http:\/\/reu.engr.uga.edu\/?p=1087"},"modified":"2018-12-18T15:08:07","modified_gmt":"2018-12-18T20:08:07","slug":"high-z-nanoparticles-as-radiosensitizers-for-cancer-therapy","status":"publish","type":"post","link":"https:\/\/reu.engr.uga.edu\/?p=1087","title":{"rendered":"High-Z Nanoparticles as radiosensitizers for cancer therapy"},"content":{"rendered":"<p><strong><u>Project Title:<\/u><\/strong><strong>\u00a0\u00a0 <\/strong>High-Z Nanoparticles as radiosensitizers for cancer therapy<\/p>\n<p>&nbsp;<\/p>\n<p><strong><u>Project Mentors<\/u><\/strong><strong>:\u00a0<\/strong><\/p>\n<ul>\n<li><strong><u>Primary Faculty Mentor (Name, Affiliation, website and Email\/Phone): <\/u><\/strong><\/li>\n<\/ul>\n<p>Dr. Jin Xie, Ph.D<\/p>\n<p>Associate professor, Department of Chemistry<\/p>\n<p>Email: jinxie@uga.edu<\/p>\n<p>Phone: (706)-542-1933<\/p>\n<p>Website: http:\/\/xie.uga.edu\/<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong><u>Graduate Student\/PostDoc mentors (Name, Affiliation and Email\/Phone):<\/u><\/strong><\/li>\n<\/ul>\n<p>Dr. Wen Jiang<\/p>\n<p>Department of Chemistry<\/p>\n<p>Email: Wen.Jiang@uga.edu<\/p>\n<p>&nbsp;<\/p>\n<p>Mr. Zhengwei Cao<\/p>\n<p>Department of Chemistry<\/p>\n<p>Email: zwcao@uga.edu<\/p>\n<p>&nbsp;<\/p>\n<p><strong><u>Project Description:<\/u><\/strong><\/p>\n<p>External radiotherapy (RT) remains a mainstay option for cancer treatment. Despite advances in radiation delivery, normal tissue exposure is inevitable. This limits the amount of radiation that can be given to a patient and often times restricts the efficacy of tumor control. To improve, it is proposed that nanoparticles made of high-Z elements are used during radiation therapy. These nanoparticles are expected to accumulate in tumors and, with their large cross-section, enhance energy deposition in tumors and augment cancer cell killing at a given radiation dose. In this project, we aim to synthesize alkaline tungstate nanoparticles and explore their roles as radiosensitizers in radiation therapy.<\/p>\n<p>&nbsp;<\/p>\n<p><strong><u>\u00a0<\/u><\/strong><\/p>\n<p><strong><u>REU Student Role and Responsibility:<\/u><\/strong><\/p>\n<p>The student will learn how to use hydrothermal method to synthesize CaWO<sub>4 <\/sub>nanoparticles of different sizes and coatings. He\/she will characterize the resulting the nanoparticles by TEM, DLS, and ICP. The efficiency of the nanoparticles as radiosensitizers will be evaluated both in solutions and with cancer cells.<\/p>\n<p>&nbsp;<\/p>\n<p><strong><u>Required skills or courses for the REU student:<\/u><\/strong><\/p>\n<p>The student should have a good chemistry and biology background. Experiences with cell culture studies are preferred.<\/p>\n<p>&nbsp;<\/p>\n<p><strong><u>\u00a0<\/u><\/strong><\/p>\n<p><strong><u>Expected Outcome for REU student:<\/u><\/strong><\/p>\n<p>The student will submit an abstract to the BMES annual meeting. If the project is successful, co-author journal publications are expected.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Project Title:\u00a0\u00a0 High-Z Nanoparticles as radiosensitizers for cancer therapy &nbsp; Project Mentors:\u00a0 Primary Faculty Mentor (Name, Affiliation, website and Email\/Phone): Dr. Jin Xie, Ph.D Associate&#8230;<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[94,7],"tags":[],"class_list":["post-1087","post","type-post","status-publish","format-standard","hentry","category-2019-projects","category-research-projects"],"_links":{"self":[{"href":"https:\/\/reu.engr.uga.edu\/index.php?rest_route=\/wp\/v2\/posts\/1087","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/reu.engr.uga.edu\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/reu.engr.uga.edu\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/reu.engr.uga.edu\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/reu.engr.uga.edu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1087"}],"version-history":[{"count":1,"href":"https:\/\/reu.engr.uga.edu\/index.php?rest_route=\/wp\/v2\/posts\/1087\/revisions"}],"predecessor-version":[{"id":1088,"href":"https:\/\/reu.engr.uga.edu\/index.php?rest_route=\/wp\/v2\/posts\/1087\/revisions\/1088"}],"wp:attachment":[{"href":"https:\/\/reu.engr.uga.edu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1087"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/reu.engr.uga.edu\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1087"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/reu.engr.uga.edu\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1087"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}